Your smile won't affect me: Association between childhood maternal antipathy and adult neural reward function in a transdiagnostic sample.

ABSTRACT: Aberrant activation in the ventral striatum (VS) during reward anticipation may be a key mechanism linking adverse childhood experiences (ACE) to transdiagnostic psychopathology. This study aimed to elucidate whether retrospectively reported ACE, specifically maternal antipathy, relate to monetary and social reward anticipation in a transdiagnostic adult sample. A cross-sectional neuroimaging study was conducted in 118 participants with varying levels of ACE, including 25 participants with posttraumatic stress disorder (PTSD), 32 with major depressive disorder (MDD), 29 with somatic symptom disorder (SSD), and 32 healthy volunteers (HVs). Participants underwent functional magnetic resonance imaging during a monetary and social incentive delay task, and completed a self-report measure of AC

SUBMITTER: Seitz KI 

PROVIDER: S-EPMC9958053 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature