The pan-cancer landscape of abnormal DNA methylation and intratumor microorganisms.

ABSTRACT: Microorganisms play very important roles in carcinogenesis, tumor progression, and resistance upon treatment. Due to the challenge of accurately acquiring samples and quantifying low-biomass tissue microorganisms, most studies have focused on the effect of gut microorganisms on cancer treatments, especially the efficacy of immunotherapy. Although recent publications reveal the potential interactions between intratumor microorganisms and the immune microenvironment, whether and to what extent the intratumor microorganism could affect progression and treatment outcome remain controversial. This study is aiming to evaluate the associations among intratumor microorganisms, DNA methylation cancer driver genes, immune response, and clinical outcomes from a pan-cancer perspective, using 6,876 TCG

SUBMITTER: Zhou P 

PROVIDER: S-EPMC9958063 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature