Spatiotemporal profile of neutrophil extracellular trap formation in a mouse model of ischemic stroke.

ABSTRACT:

Background

Thromboinflammatory processes modulate the complex pathophysiology of cerebral ischemia-reperfusion (I/R) injury in ischemic stroke, but the exact underlying mechanisms remain poorly understood. Emerging evidence indicates that neutrophil extracellular traps (NETs) might play an important role in the thromboinflammatory cascade. In addition, the link between von Willebrand factor (VWF) and neutrophil recruitment in the ischemic brain might promote thromboinflammation, possibly by the formation of NETs.

Objectives

To study NET formation in a murine model of cerebral I/R injury in ischemic stroke.

Methods

The filament-induced transient middle cerebral artery occlusion model was used to induce 60 minutes of focal cerebral ischemia after which reperfusion was a

SUBMITTER: De Wilde M 

PROVIDER: S-EPMC9958086 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature