Rewiring of the N-Glycome with prostate cancer progression and therapy resistance.

ABSTRACT: An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival. The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface. Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease rem

SUBMITTER: Butler W 

PROVIDER: S-EPMC9958128 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature