Identification of conserved genomic signatures specific to Bifidobacterium species colonising the human gut.

ABSTRACT: Bifidobacterium species are known for their ability to inhabit various habitats and are often regarded as the first colonisers of the human gut. In the present work, we have used comparative genomics to identify conserved genomic signatures specific to Bifidobacterium species associated with the human gut. Our approach discovered five genomic signatures with varying lengths and confidence. Among the predicted five signatures, a 1790 bp multi-drug resistance (MDR) signature was found to be remarkably specific to only those species that can colonise the human gut. The signature codes for a membrane transport protein belonging to the major facilitator superfamily (MFS) generally involved in MDR. Phylogenetic analyses of the MDR signature suggest a lineage-specific evolution of t

SUBMITTER: Arjun OK 

PROVIDER: S-EPMC9958220 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature