Vitamin B_6, B₁₂ and folate modulate deregulated pathways and protein aggregation in yeast model of Huntington disease.

ABSTRACT: Huntington's disease (HD) is an incurable and progressive neurodegenerative disease affecting the basal ganglia of the brain. HD is caused due to expansion of the polyglutamine tract in the protein Huntingtin resulting in aggregates. The increased PolyQ length results in aggregation of protein Huntingtin leading to neuronal cell death. Vitamin B₆, B₁₂ and folate are deficient in many neurodegenerative diseases. We performed an integrated analysis of transcriptomic, metabolomic and cofactor-protein network of vitamin B₆, B₁₂ and folate was performed. Our results show considerable overlap of pathways modulated by Vitamin B₆, B₁₂ and folate with those obtained from transcriptomic and metabolomic data of HD patients and model sy

SUBMITTER: Pradhan SS 

PROVIDER: S-EPMC9958225 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature