Neuromuscular and cardiac adverse events associated with immune checkpoint inhibitors: pooled analysis of individual cases from multiple institutions and literature.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have revolutionized the management of multiple tumors, due to improved efficacy, quality of life, and safety. While most immune-related adverse events (irAEs) are mild and easily managed, in rare cases such events may be life-threatening, especially those affecting the neuromuscular and cardiac system. The management of neuromuscular/cardiac irAEs is not clear due to the lack of consistent data. Therefore, we carried out a pooled analysis of collected cases from selected Italian centers and individual data from published case reports and case series, in order to improve our understanding of these irAEs.

Patients and methods

We collected retrospective data from patients treated in six Italian centers with ICIs (programmed cell de

SUBMITTER: Boutros A 

PROVIDER: S-EPMC9958259 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature