The Association between Prenatal Nicotine Exposure and Offspring's Hearing Impairment.

ABSTRACT:

Objective

 The objective of this study is to evaluate whether there is an association between in-utero exposure to nicotine and subsequent hearing dysfunction.

Patients and methods

 Secondary analysis of a multicenter randomized trial to prevent congenital cytomegalovirus (CMV) infection among gravidas with primary CMV infection was conducted. Monthly intravenous immunoglobulin hyperimmune globulin therapy did not influence the rate of congenital CMV. Dyads with missing urine, fetal or neonatal demise, infants diagnosed with a major congenital anomaly, congenital CMV infection, or with evidence of middle ear dysfunction were excluded. The primary outcome was neonatal hearing impairment in one or more ears defined as abnormal distortion product otoacoustic emissions (DPOAEs;

SUBMITTER: Cleary EM 

PROVIDER: S-EPMC9958273 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature