Protection from T cell-dependent colitis by the helminth-derived immunomodulatory mimic of transforming growth factor-β, <i>Hp</i>-TGM.

ABSTRACT: In animal models of inflammatory colitis, pathology can be ameliorated by several intestinal helminth parasites, including the mouse nematode Heligmosomoides polygyrus. To identify parasite products that may exert anti-inflammatory effects in vivo, we tested H. polygyrus excretory-secretory (HES) products, as well as a recombinantly expressed parasite protein, transforming growth factor mimic (TGM), that functionally mimics the mammalian immunomodulatory cytokine TGF-β. HES and TGM showed a degree of protection in dextran sodium sulphate-induced colitis, with a reduction in inflammatory cytokines, but did not fully block the development of pathology. HES also showed little benefit in a similar acute trinitrobenzene sulphonic acid-induced model. However, in a T cell tra

SUBMITTER: Smyth DJ 

PROVIDER: S-EPMC9958376 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature