Personalized maps of T1 relaxometry abnormalities provide correlates of disability in multiple sclerosis patients.

ABSTRACT:

Objectives and aims

Quantitative MRI (qMRI) has greatly improved the sensitivity and specificity of microstructural brain pathology in multiple sclerosis (MS) when compared to conventional MRI (cMRI). More than cMRI, qMRI also provides means to assess pathology within the normal-appearing and lesion tissue. In this work, we further developed a method providing personalized quantitative T1 (qT1) abnormality maps in individual MS patients by modeling the age dependence of qT1 alterations. In addition, we assessed the relationship between qT1 abnormality maps and patients' disability, in order to evaluate the potential value of this measurement in clinical practice.

Methods

We included 119 MS patients (64 relapsing-remitting MS (RRMS), 34 secondary progressive MS (SPMS), 21 pri

SUBMITTER: Chen X 

PROVIDER: S-EPMC9958406 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature