New statistical approach shows that hydroxy-methionine is noninferior to DL-Methionine in 35-day-old broiler chickens.

ABSTRACT: The efficacy of a new molecule is assessed in the pharmaceutical industry through noninferiority tests to establish that it is not unacceptably less efficient than the reference. This method was proposed to compare DL-Methionine (DL-Met) as reference and DL-Hydroxy-Methionine (OH-Met) as alternative, in broiler chickens. The research hypothesized that OH-Met is inferior to DL-Met. Noninferiority margins were determined using 7 datasets comparing broiler growth response between a sulfur amino acid deficient and adequate diet from 0 to 35 d. The datasets were selected from the literature and internal records of the company. The noninferiority margins were then fixed as the largest loss of effect (inferiority) acceptable when OH-Met is compared to DL-Met. Three corn/soybean meal-based experim

SUBMITTER: Batonon-Alavo DI 

PROVIDER: S-EPMC9958497 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature