Targeting the aryl hydrocarbon receptor by gut phenolic metabolites: A strategy towards gut inflammation.

ABSTRACT: The Aryl Hydrocarbon Receptor (AHR) is a ligand-dependent transcription factor able to control complex transcriptional processes in several cell types, which has been correlated with various diseases, including inflammatory bowel diseases (IBD). Numerous studies have described different compounds as ligands of this receptor, like xenobiotics, natural compounds, and several host-derived metabolites. Dietary (poly)phenols have been studied regarding their pleiotropic activities (e.g., neuroprotective and anti-inflammatory), but their AHR modulatory capabilities have also been considered. However, dietary (poly)phenols are submitted to extensive metabolism in the gut (e.g., gut microbiota). Thus, the resulting gut phenolic metabolites could be key players modulating AHR since they are the one

SUBMITTER: Pinto CJG 

PROVIDER: S-EPMC9958510 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature