Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility.

ABSTRACT:

Importance

Frequent aspirin use is associated with reduced ovarian cancer risk, but it is unknown whether genetic factors modify this association. Understanding effect modifiers is important given that any use of aspirin for ovarian cancer chemoprevention will likely need to focus on specific higher-risk subgroups.

Objective

To evaluate whether the association between frequent aspirin use and ovarian cancer is modified by a polygenic score (PGS) for nonmucinous ovarian cancer.

Design, setting, and participants

We pooled individual-level data from 8 population-based case-control studies from the Ovarian Cancer Association Consortium conducted in the US, UK, and Australia between 1995 and 2009. We included case patients and control participants with both genetic data an

SUBMITTER: Hurwitz LM 

PROVIDER: S-EPMC9958519 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature