Evaluation of Systemic Treatments of Small Intestinal Adenocarcinomas: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Although small intestinal adenocarcinomas (SIAs) are rare, they have a poor prognosis, and the optimal treatment strategies are largely unknown. Because of the lack of high-quality evidence, guidelines for colorectal cancer are often followed in the treatment of SIAs.

Objective

To review the current evidence regarding survival benefit of systemic therapies, including chemotherapy, targeted agents, and immunotherapy, for patients with SIAs.

Data sources

Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses, MEDLINE and Embase were searched for articles published from January 1, 2005, until June 1, 2022.

Study selection

Retrospective cohort studies and prospective phase 2 or 3 trials describing survival after systemic therapi

SUBMITTER: de Back T 

PROVIDER: S-EPMC9958532 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature