Marburg and Ebola Virus Infections Elicit a Complex, Muted Inflammatory State in Bats.

ABSTRACT: The Marburg and Ebola filoviruses cause a severe, often fatal, disease in humans and nonhuman primates but have only subclinical effects in bats, including Egyptian rousettes, which are a natural reservoir of Marburg virus. A fundamental question is why these viruses are highly pathogenic in humans but fail to cause disease in bats. To address this question, we infected one cohort of Egyptian rousette bats with Marburg virus and another cohort with Ebola virus and harvested multiple tissues for mRNA expression analysis. While virus transcripts were found primarily in the liver, principal component analysis (PCA) revealed coordinated changes across multiple tissues. Gene signatures in kidney and liver pointed at induction of vasodilation, reduction in coagulation, and changes in the regulat

SUBMITTER: Jayaprakash AD 

PROVIDER: S-EPMC9958679 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature