Orthodontic Compression Enhances Macrophage M2 Polarization via Histone H3 Hyperacetylation.

ABSTRACT: Orthodontic tooth movement is a complex periodontal remodeling process triggered by compression that involves sterile inflammation and immune responses. Macrophages are mechanically sensitive immune cells, but their role in orthodontic tooth movement is unclear. Here, we hypothesize that orthodontic force can activate macrophages, and their activation may be associated with orthodontic root resorption. After force-loading and/or adiponectin application, the migration function of macrophages was tested via scratch assay, and Nos2, Il1b, Arg1, Il10, ApoE, and Saa3 expression levels were detected using qRT-PCR. Furthermore, H3 histone acetylation was measured using an acetylation detection kit. The specific inhibitor of H3 histone, I-BET762, was deplo

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9958841 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature