Functionally Validating Evolutionary Conserved Risk Genes for Parkinson's Disease in Drosophila melanogaster.

ABSTRACT: Parkinson's disease (PD) is a heterogeneous and complex neurodegenerative disorder and large-scale genetic studies have identified >130 genes associated with PD. Although genomic studies have been decisive for our understanding of the genetic contributions underlying PD, these associations remain as statistical associations. Lack of functional validation limits the biological interpretation; however, it is labour extensive, expensive, and time consuming. Therefore, the ideal biological system for functionally validating genetic findings must be simple. The study aim was to assess systematically evolutionary conserved PD-associated genes using Drosophila melanogaster. From a literature review, a total of 136 genes have found to be associated with PD in GWAS studies, of which 11 are s

SUBMITTER: Baisgaard AE 

PROVIDER: S-EPMC9958964 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature