Dual Effect of Chemo-PDT with Tumor Targeting Nanoparticles Containing iRGD Peptide.

ABSTRACT: Nanotechnology, including self-aggregated nanoparticles, has shown high effectiveness in the treatment of solid tumors. To overcome the limitations of conventional cancer therapies and promote therapeutic efficacy, a combination of PDT and chemotherapy can be considered an effective strategy for cancer treatment. This study presents the development of tumor-targeting polysialic acid (PSA) nanoparticles for chemo-PDT to increase the cellular uptake and cytotoxic effect in cancer cells. Chlorin e6 (Ce6), a photosensitizer, and the iRGD peptide (sequence; cCRGDKGPDC) were conjugated to the amine of N-deacetylated PSA. They generate reactive oxygen species (ROS), especially singlet oxygen (¹O₂), and target integrin αvβ3 on the cancer cell surface. To offer a chemot

SUBMITTER: Kim GL 

PROVIDER: S-EPMC9959063 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature