Helicobacter pylori Virulence Factors and Clarithromycin Resistance-Associated Mutations in Mexican Patients.

ABSTRACT: Persistent infection with Helicobacter pylori (H. pylori) is an important factor in gastric diseases. The vacA and cagA virulence factors of H. pylori contribute to the development of these diseases. Triple therapy containing clarithromycin has been used to eradicate this infection. Unfortunately, resistance to this antibiotic is the primary cause of treatment failure. This study aimed to determine the prevalence of clarithromycin resistance-associated mutations and to assess the relationship between virulence factors and Mexican patients infected with H. pylori. The cagA and vacA genotypes were determined by multiplex PCR. Furthermore, a qPCR was used to identify mutations of the 23S rRNA gene. This study reported a prevalence of 84.3% of H. pylori

SUBMITTER: Alarcon-Millan J 

PROVIDER: S-EPMC9959081 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature