Unknown

Dataset Information

0

Briavioids E-G, Newly Isolated Briarane-Diterpenoids from a Cultured Octocoral Briareum violaceum.

ABSTRACT: The chemical screening of a cultured soft coral, Briareum violaceum, led to the isolation of eight natural, briarane-related diterpenoids, including three unreported metabolites, briavioids E-G (1-3), and five known briaranes, briacavatolides B (4) and C (5), briaexcavatin L (6), briaexcavatolide U (7) and briarenol K (8). The structures of briaranes 1-8 were established using spectroscopic methods. The absolute configuration of briavioid A (9), obtained in a previous study, was reported for the first time in this study by a single-crystal X-ray diffraction analysis using a copper radiation source. The anti-inflammatory activity of briaranes 1 and 2 and briaranes 4-8 was evaluated by screening their inhibitory ability against the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells.

SUBMITTER: Huynh TH 

PROVIDER: S-EPMC9959093 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Briavioids E-G, Newly Isolated Briarane-Diterpenoids from a Cultured Octocoral <i>Briareum violaceum</i>.

Huynh Thanh Hao TH   Liu Chia-Jung CJ   Liu Yi-Hung YH   Chien Su-Ying SY   Wen Zhi-Hong ZH   Fang Lee-Shing LS   Chen Jih-Jung JJ   Wu Yang-Chang YC   Su Jui-Hsin JH   Sung Ping-Jyun PJ  

Marine drugs 20230214 2

The chemical screening of a cultured soft coral, <i>Briareum violaceum</i>, led to the isolation of eight natural, briarane-related diterpenoids, including three unreported metabolites, briavioids E-G (<b>1</b>-<b>3</b>), and five known briaranes, briacavatolides B (<b>4</b>) and C (<b>5</b>), briaexcavatin L (<b>6</b>), briaexcavatolide U (<b>7</b>) and briarenol K (<b>8</b>). The structures of briaranes <b>1</b>-<b>8</b> were established using spectroscopic methods. The absolute configuration  ...[more]

Similar Datasets

Unknown Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum.
| S-EPMC5867619 | biostudies-literature
Unknown Briarane-Related Diterpenoids from Octocoral Briareum stechei.
| S-EPMC8619598 | biostudies-literature
Unknown Briarenolides K and L, new anti-inflammatory briarane diterpenoids from an octocoral Briareum sp. (Briareidae).
| S-EPMC4344617 | biostudies-literature
Unknown Polyoxygenated Klysimplexane- and Eunicellin-Based Diterpenoids from the Gorgonian Briareum violaceum.
| S-EPMC8198191 | biostudies-literature
Unknown Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum.
| S-EPMC6409734 | biostudies-literature
Unknown Absolute configuration by vibrational circular dichroism of anti-inflammatory macrolide briarane diterpenoids from the Gorgonian Briareum asbestinum.
| S-EPMC7804146 | biostudies-literature
Unknown Briarenols Q-T: Briaranes from A Cultured Octocoral Briareum stechei (Kukenthal, 1908).
| S-EPMC7460508 | biostudies-literature
Unknown seco-Briarellinone and briarellin S, two new eunicellin-based diterpenoids from the Panamanian octocoral Briareum asbestinum.
| S-EPMC3509539 | biostudies-literature
Unknown New Furanocembranoids from Briareum violaceum.
| S-EPMC6520705 | biostudies-literature
Unknown Briarane diterpenoids from the gorgonian Dichotella gemmacea.
| S-EPMC4278224 | biostudies-literature