De Novo Transcriptome Profiling of Naegleria fowleri Trophozoites and Cysts via RNA Sequencing.

ABSTRACT: Naegleria fowleri is a pathogenic free-living amoeba, commonly found around the world in warm, fresh water and soil. N. fowleri trophozoites can infect humans by entering the brain through the nose and causing usually fatal primary amebic meningoencephalitis (PAM). Trophozoites can encyst to survive under unfavorable conditions such as cold temperature, starvation, and desiccation. Recent technological advances in genomics and bioinformatics have provided unique opportunities for the identification and pre-validation of pathogen-related and environmental resistance through improved understanding of the biology of pathogenic N. fowleri trophozoites and cysts at a molecular level. However, genomic and transcriptomic data on differential expression genes (DEGs) between tr

SUBMITTER: Sohn HJ 

PROVIDER: S-EPMC9959186 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature