The Titrated Mannitol Improved Central [^99mTc] Tc TRODAT-1 Uptake in an Animal Model-A Clinically Feasible Application.

ABSTRACT: [^99mTc]Tc TRODAT-1 is a widely used single photon emission tomography (SPECT) radiopharmaceutical in Asian practice for early detection of central dopaminergic disorders. However, its imaging quality remains sub-optimal. To overcome this problem, mannitol, an osmotic agent was used to observe its effect on improving striatal [^99mTc]Tc TRODAT-1 uptake in rat brain by titrated human dosages to investigate a clinically feasible way to improve human imaging quality. [^99mTc]Tc TRODAT-1 synthesis and quality control were performed as described. Sprague-Dawley rats were used for this study. The animal in vivo nanoSPECT/CT and ex vivo autoradiography were employed to observe and verify the striatal [^99mTc]Tc TRODAT-1 uptake in rat brains using clinically

SUBMITTER: Chang KW 

PROVIDER: S-EPMC9959225 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature