Strategies to Prevent Early and Late-Onset Group B Streptococcal Infection via Interventions in Pregnancy.

ABSTRACT: Group B Streptococcus is a Gram-positive bacterium that typically colonizes 10-30% of pregnant women, causing chorioamnionitis, preterm birth, and stillbirth, as well as neonatal sepsis and meningitis with early-onset disease (EOD) or late-onset disease (LOD) due to ascending infection or transmission during delivery. While there are some differences between EOD and LOD in terms of route of transmission, risk factors, and serotypes, the only preventive approach currently is maternal intrapartum antibiotic prophylaxis (IAP) which will not be able to fully address the burden of the disease since this has no impact on LOD. Probiotics and immunization in pregnancy may be more effective than IAP for both EOD and LOD. There is mixed evidence of probiotic effects on the prevention of GBS c

SUBMITTER: Delara M 

PROVIDER: S-EPMC9959229 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature