Discovery of Polyphenolic Natural Products as SARS-CoV-2 M^pro Inhibitors for COVID-19.

ABSTRACT: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the development of direct-acting antiviral drugs due to the coronavirus disease 2019 (COVID-19) pandemic. The main protease of SARS-CoV-2 is a crucial enzyme that breaks down polyproteins synthesized from the viral RNA, making it a validated target for the development of SARS-CoV-2 therapeutics. New chemical phenotypes are frequently discovered in natural goods. In the current study, we used a fluorogenic assay to test a variety of natural products for their ability to inhibit SARS-CoV-2 M^pro. Several compounds were discovered to inhibit M^pro at low micromolar concentrations. It was possible to crystallize robinetin together with SARS-CoV-2 M^pro, and the X-ray structure revealed cov

SUBMITTER: Kruger N 

PROVIDER: S-EPMC9959258 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature