Genetic Risk Scores for the Determination of Type 2 Diabetes Mellitus (T2DM) in North India.

ABSTRACT:

Background

Globally, type 2 diabetes mellitus (T2DM) is one of the fastest-growing noncommunicable multifactorial and polygenic diseases, which leads to many health complications and significant morbidity and mortality. South Asians have a high genetic predisposition to T2DM, with India being home to one in six diabetics. This study investigates the association of selected genetic polymorphisms with T2DM risk and develops a polygenic risk score (PRS).

Methods

A case-control study recruited fully consented participants from a population of Jat Sikhs in north India. DNA samples were genotyped for a range of polymorphisms and odds ratios were calculated under several genetic association models. Receiver operating characteristic (ROC) curves were produced for combinations of the

SUBMITTER: Shitomi-Jones LM 

PROVIDER: S-EPMC9959290 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature