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Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand.

ABSTRACT: Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3-8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from H. littoralis was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound 2 substantially inhibits the release of nitric oxide (NO) with an IC₅₀ value of 10.33 μM. The triterpenoids from H. littoralis could be used as potential candidates for the development of new anti-inflammatory agents.

SUBMITTER: Liang X

PROVIDER: S-EPMC9959541 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand.

Liang Xiaoqin X Niu Peng P Li Jun J Guan Xinlan X Zhang Yanjun Y Li Jian J

Molecules (Basel, Switzerland) 20230209 4

Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3-8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from H. littoralis was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids ...[more]

PMID: 36838650

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