A CO₂-Responsive Imidazole-Functionalized Fluorescent Material Mediates Cancer Chemotherapy.

ABSTRACT: We present a breakthrough in the synthesis and development of functional gas-responsive materials as highly potent anticancer agents suitable for applications in cancer treatment. Herein, we successfully synthesised a stimuli-responsive multifunctional material (I-R6G) consisting of a carbon dioxide (CO₂)-sensitive imidazole moiety and spirolactam-containing conjugated rhodamine 6G (R6G) molecule. The resulting I-R6G is highly hydrophobic and non- or weakly fluorescent. Simple CO₂ bubbling treatment induces hydrophobic I-R6G to completely dissolve in water and subsequently form self-assembled nanoparticles, which exhibit unique optical absorption and fluorescence behaviours in water and extremely low haemolytic ability against sheep red blood cells. Reversibility test

SUBMITTER: Ngan VTT 

PROVIDER: S-EPMC9959563 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature