Synthesis of Multi-Stimuli Responsive Fe₃O₄ Coated with Diamonds Nanocomposite for Magnetic Assisted Chemo-Photothermal Therapy.

ABSTRACT: Nanodiamonds with magnetic resonance imaging (MRI) and targeted drug delivery to exert combined effects for biomedical applications have been considered to be an urgent challenge. Herein, a novel bio-nanoarchitectonics (Fe₃O₄@NDs) with simultaneous imaging and therapeutic capacities was fabricated by covalently conjugating nanodiamonds (NDs) with Fe₃O₄. Fe₃O₄@NDs exhibited better biocompatibility and excellent photothermal stability with superb photothermal conversion performance (37.2%). Fe₃O₄@NDs has high doxorubicin (DOX) loading capacity (193 mg/g) with pH and NIR-responsive release characteristics. Fe₃O₄@NDs loading DOX showed a combined chemo-photothermal inhibitory effect on

SUBMITTER: Li Y 

PROVIDER: S-EPMC9959610 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature