Borate Transporters and SLC4 Bicarbonate Transporters Share Key Functional Properties.

ABSTRACT: Borate transporters are membrane transport proteins that regulate intracellular borate levels. In plants, borate is a micronutrient essential for growth but is toxic in excess, while in yeast, borate is unnecessary for growth and borate export confers tolerance. Borate transporters share structural homology with human bicarbonate transporters in the SLC4 family despite low sequence identity and differences in transported solutes. Here, we characterize the S. cerevisiae borate transporter Bor1p and examine whether key biochemical features of SLC4 transporters extend to borate transporters. We show that borate transporters and SLC4 transporters share multiple properties, including lipid-promoted dimerization, sensitivity to stilbene disulfonate-derived inhibitors, and a requirement fo

SUBMITTER: Beltran JL 

PROVIDER: S-EPMC9959716 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature