A Protein Co-Conservation Network Model Characterizes Mutation Effects on SARS-CoV-2 Spike Protein.

ABSTRACT: The emergence of numerous variants of SARS-CoV-2 has presented challenges to the global efforts to control the COVID-19 pandemic. The major mutation is in the SARS-CoV-2 viral envelope spike protein that is responsible for virus attachment to the host, and is the main target for host antibodies. It is critically important to study the biological effects of the mutations to understand the mechanisms of how mutations alter viral functions. Here, we propose a protein co-conservation weighted network (PCCN) model only based on the protein sequence to characterize the mutation sites by topological features and to investigate the mutation effects on the spike protein from a network view. Frist, we found that the mutation sites on the spike protein had significantly larger centrality than the non

SUBMITTER: Zeng L 

PROVIDER: S-EPMC9960056 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature