The Search of Association of HLA Class I and Class II Alleles with COVID-19 Mortality in the Russian Cohort.

ABSTRACT: HLA genes play a pivotal role in the immune response via presenting the pathogen peptides on the cell surface in a host organism. Here, we studied the association of HLA allele variants of class I (loci A, B, C) and class II (loci DRB1, DQB1, DPB1) genes with the outcome of COVID-19 infection. We performed high-resolution sequencing of class HLA I and class II genes based on the sample population of 157 patients who died from COVID-19 and 76 patients who survived despite severe symptoms. The results were further compared with HLA genotype frequencies in the control population represented by 475 people from the Russian population. Although the obtained data revealed no significant differences between the samples at a locus level, they allowed one to uncover a set of notable alleles potentia

SUBMITTER: Cheranev V 

PROVIDER: S-EPMC9960097 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature