Inheritance of perturbed methylation and metabolism caused by uterine malnutrition via oocytes.

ABSTRACT:

Background

Undernourishment in utero has deleterious effects on the metabolism of offspring, but the mechanism of the transgenerational transmission of metabolic disorders is not well known. In the present study, we found that undernourishment in utero resulted in metabolic disorders of female F1 and F2 in mouse model.

Results

Undernutrition in utero induced metabolic disorders of F1 females, which was transmitted to F2 females. The global methylation in oocytes of F1 exposed to undernutrition in utero was decreased compared with the control. KEGG analysis showed that genes with differential methylation regions (DMRs) in promoters were significantly enriched in metabolic pathways. The altered methylation of some DMRs in F1 oocytes located at the promoters of metabolic-relate

SUBMITTER: Tang SB 

PROVIDER: S-EPMC9960220 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature