Ontology highlight
ABSTRACT:
SUBMITTER: Rybchenko VS
PROVIDER: S-EPMC9960319 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Rybchenko Vladislav S VS Aliev Teimur K TK Panina Anna A AA Kirpichnikov Mikhail P MP Dolgikh Dmitry A DA
Pharmaceutics 20230119 2
Anti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity. These factors significantly limit clinical applications. Due to their high specificity and affinity, tumor-specific monoclonal antibodies or their antigen-binding fragments are capable of delivering fused cytokines to tumors and, therefore, of decreasing the nu ...[more]