Assessment of redundant randomized clinical trials among patients with ST segment elevation myocardial infarction.

ABSTRACT:

Background

Redundant clinical trials waste resources and unnecessarily put patients at risk for harm. The objectives of the study were to assess redundant randomized clinical trials (RCTs) conducted in mainland China or the USA among patients with ST segment elevation myocardial infarction (STEMI) and estimate the harm to patients enrolled in redundant RCTs.

Methods

We searched bibliographic databases for eligible RCTs comparing a routine therapy with a placebo or no treatment among patients with STEMI in mainland China or the United States. The routine therapy for STEMI included reperfusion (percutaneous coronary intervention or fibrinolytic therapy), P2Y₁₂ receptor inhibitors, statins, and anticoagulants. Redundant RCTs were defined as those initiated or continu

SUBMITTER: Jia Y 

PROVIDER: S-EPMC9960404 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature