Plasma neurofilament light is a predictor of neurological outcome 12 h after cardiac arrest.

ABSTRACT:

Background

Previous studies have reported high prognostic accuracy of circulating neurofilament light (NfL) at 24-72 h after out-of-hospital cardiac arrest (OHCA), but performance at earlier time points and after in-hospital cardiac arrest (IHCA) is less investigated. We aimed to assess plasma NfL during the first 48 h after OHCA and IHCA to predict long-term outcomes.

Methods

Observational multicentre cohort study in adults admitted to intensive care after cardiac arrest. NfL was retrospectively analysed in plasma collected on admission to intensive care, 12 and 48 h after cardiac arrest. The outcome was assessed at two to six months using the Cerebral Performance Category (CPC) scale, where CPC 1-2 was considered a good outcome and CPC 3-5 a poor outcome. Predictive perfor

SUBMITTER: Levin H 

PROVIDER: S-EPMC9960417 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature