Integrated multi-omics analyses and functional validation reveal TTK as a novel EMT activator for endometrial cancer.

ABSTRACT:

Background

Cancer-testis antigens (CTAs) are often expressed in tumor and testicular tissues but not in other normal tissues. To date, there has been no comprehensive study of the expression and clinical significance of CTA genes associated with endometrial cancer (EC) development. Additionally, the clinical relevance, biological role, and molecular mechanisms of the CTA gene TTK protein kinase (TTK) in EC are yet to be fully understood.

Methods

Using bioinformatics methods, we comprehensively investigated the genomic, transcriptomic, and epigenetic changes associated with aberrant TTK overexpression in EC samples from the TCGA database. We further investigated the mechanisms of the lower survival associated with TTK dysregulation using single-cell data of EC samples from th

SUBMITTER: Miao Y 

PROVIDER: S-EPMC9960418 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature