Differential Expression of MED12-Associated Coding RNA Transcripts in Uterine Leiomyomas.

ABSTRACT: Recent studies have demonstrated that somatic MED12 mutations in exon 2 occur at a frequency of up to 80% and have a functional role in leiomyoma pathogenesis. The objective of this study was to elucidate the expression profile of coding RNA transcripts in leiomyomas, with and without these mutations, and their paired myometrium. Next-generation RNA sequencing (NGS) was used to systematically profile the differentially expressed RNA transcripts from paired leiomyomas (n = 19). The differential analysis indicated there are 394 genes differentially and aberrantly expressed only in the mutated tumors. These genes were predominantly involved in the regulation of extracellular constituents. Of the differentially expressed genes that overlapped in the two comparison groups, the magnitude of chan

SUBMITTER: Chuang TD 

PROVIDER: S-EPMC9960582 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature