Optimizing Dacarbazine Therapy: Design of a Laser-Triggered Delivery System Based on β-Cyclodextrin and Plasmonic Gold Nanoparticles.

ABSTRACT: Dacarbazine (DB) is an antineoplastic drug extensively used in cancer therapy. However, present limitations on its performance are related to its low solubility, instability, and non-specificity. To overcome these drawbacks, DB was included in β-cyclodextrin (βCD), which increased its aqueous solubility and stability. This new βCD@DB complex has been associated with plasmonic gold nanoparticles (AuNPs), and polyethylene glycol (PEG) has been added in the process to increase the colloidal stability and biocompatibility. Different techniques revealed that DB allows for a dynamic inclusion into βCD, with an association constant of 80 M^-1 and a degree of solubilization of 0.023, where βCD showed a loading capacity of 16%. The partial exposure of the NH₂ group in the inclu

SUBMITTER: Quintana-Contardo S 

PROVIDER: S-EPMC9960602 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature