Polymer-Antimicrobial Peptide Constructs with Tailored Drug-Release Behavior.

ABSTRACT: Microbial resistance is one of the main problems of modern medicine. Recently, antimicrobial peptides have been recognized as a novel approach to overcome the microbial resistance issue, nevertheless, their low stability, toxicity, and potential immunogenic response in biological systems have limited their clinical application. Herein, we present the design, synthesis, and preliminary biological evaluation of polymer-antibacterial peptide constructs. The antimicrobial GKWMKLLKKILK-NH₂ oligopeptide (PEP) derived from halictine, honey bee venom, was bound to a polymer carrier via various biodegradable spacers employing the pH-sensitive or enzymatically-driven release and reactivation of the PEP's antimicrobial activity. The antibacterial properties of the polymer-PEP constructs we

SUBMITTER: Pola R 

PROVIDER: S-EPMC9960778 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature