The Antidepressant Sertraline Affects Cell Signaling and Metabolism in Trichophyton rubrum.

ABSTRACT: The dermatophyte Trichophyton rubrum is responsible for most human cutaneous infections. Its treatment is complex, mainly because there are only a few structural classes of fungal inhibitors. Therefore, new strategies addressing these problems are essential. The development of new drugs is time-consuming and expensive. The repositioning of drugs already used in medical practice has emerged as an alternative to discovering new drugs. The antidepressant sertraline (SRT) kills several important fungal pathogens. Accordingly, we investigated the inhibitory mechanism of SRT in T. rubrum to broaden the knowledge of its impact on eukaryotic microorganisms and to assess its potential for future use in dermatophytosis treatments. We performed next-generation sequencing (RNA-seq) to id

SUBMITTER: Galvao-Rocha FM 

PROVIDER: S-EPMC9961077 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature