Retrospective screening of serum IgG glycosylation biomarker for primary Sjogren's syndrome using lectin microarray.

ABSTRACT:

Background

Primary Sjögren's syndrome (PSS) is a systemic autoimmune disease resulting in significant loss of systemic gland secretory function. IgG glycosylation abnormalities had been found to play important roles in autoimmune diseases. Here, we aim to explore the specific changes of IgG glycosylation in PSS patient serum that could serve as potential biomarkers for disease diagnosis and differential diagnosis.

Method

From 2012 to 2018, patients diagnosed with PSS or primary biliary cholangitis (PBC) admitted consecutively to the department of Rheumatology at Peking Union Medical College Hospital were retrospectively included in this study. Glycan profiles of serum IgG from 40 PSS patients, 50 PBC patients, and 38 healthy controls were detected with lectin microarray cont

SUBMITTER: Li S 

PROVIDER: S-EPMC9961092 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature