Interaction between Pharmaceutical Drugs and Polymer-Coated Fe₃O₄ Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models.

ABSTRACT: Surface modification of magnetic nanoparticles (MNPs) has been reported to play a significant role in determining their interactions with cell membranes. In this research, the interactions between polymer functionalized (chitosan, CHI or diethylamino-ethyl dextran, DEAE-D) Fe₃O₄ MNPs, pharmaceutical drugs and model cell membranes were investigated by Langmuir isotherms and adsorption measurements. In this study, 1,2-distearoyl-sn-glycerol-3-phosphate (DSPA) phospholipid monolayers were used as cell membrane models. Insertion experiments demonstrate that diclofenac (DCFN) is not absorbed at the air-water interface, whereas triflupromazine (TFPZ) has a MIP (maximum insertion pressure) of 35 m Nm^-1. The insertion of composites MNPs:TFPZ or DCFN has larger MIP

SUBMITTER: Moya Betancourt SN 

PROVIDER: S-EPMC9961141 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature