Physicochemical Properties and Transdermal Absorption of a Flurbiprofen and Lidocaine Complex in the Non-Crystalline Form.

ABSTRACT: Amorphous drug formulations exploiting drug-drug interactions have been extensively studied. This study aims to develop a transdermal system containing an amorphous complex of the nonsteroidal anti-inflammatory drug (NSAID) flurbiprofen (FLU) and lidocaine (LDC) for alleviating chronic pain. The high-viscosity complex between FLU and LDC (Complex) was obtained by heating in ethanol. For the complex, attenuated total reflection-Fourier transform infrared spectroscopy showed a shift in the carboxy-group-derived peak of FLU, and differential scanning calorimetry indicated the endothermic peaks associated with the melting of FLU and LDC disappeared. ¹³C dipolar decoupling and ¹⁵N cross-polarization magic-angle spinning nuclear magnetic resonance measurement suggested the

SUBMITTER: Xu Q 

PROVIDER: S-EPMC9961180 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature