Metabolomic Strategies to Improve Chemical Information from OSMAC Studies of Endophytic Fungi.

ABSTRACT: Metabolomics strategies are important tools to get holistic chemical information from a system, but they are scarcely applied to endophytic fungi to understand their chemical profiles of biosynthesized metabolites. Here Penicillium sp. was cultured using One Strain Many Compounds (OSMAC) conditions as a model system to demonstrate how this strategy can help in understanding metabolic profiles and determining bioactive metabolites with the application of metabolomics and statistical analyses, as well as molecular networking. Penicillium sp. was fermented in different culture media and the crude extracts from mycelial biomass (CEm) and broth (CEb) were obtained, evaluated against bacterial strains (Staphylococcus aureus and Pseudomonas aeruginosa), and the metabol

SUBMITTER: da Silva FMR 

PROVIDER: S-EPMC9961420 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature