ATF5 Attenuates the Secretion of Pro-Inflammatory Cytokines in Activated Microglia.

ABSTRACT: The highly dynamic changes in microglia necessary to achieve a rapid neuroinflammatory response require a supply of energy from mitochondrial respiration, which leads to the accumulation of unfolded mitochondrial proteins. We previously reported that microglial activation is correlated with the mitochondrial unfolded protein response (UPRmt) in a kaolin-induced hydrocephalus model, but we still do not know the extent to which these changes in microglia are involved in cytokine release. Here, we investigated the activation of BV-2 cells and found that treatment with lipopolysaccharide (LPS) for 48 h increased the secretion of pro-inflammatory cytokines. This increase was accompanied by a concurrent decrease in oxygen consumption rate (OCR) and mitochondrial membrane potential (MMP), in asso

SUBMITTER: Zhu J 

PROVIDER: S-EPMC9961550 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature