Insights into Synonymous Codon Usage Bias in Hepatitis C Virus and Its Adaptation to Hosts.

ABSTRACT: Hepatitis C virus (HCV) is enveloped RNA virus, encoding for a polyprotein that is processed by cellular proteases. The virus is responsible for liver cirrhosis, allograft rejection, and human hepatocellular carcinoma. Based on studies including compositional analysis, odds ratio analysis, parity analysis, skew analysis, relative synonymous codon usage, codon bias, and protein properties, it was evident that codon usage bias in HCV is dependent upon the nucleotide composition. Codon context analysis revealed CTC-CTG as a preferred codon pair. While CGA and CGT codons were rare, none of the codons were rare in HCV-like viruses envisaged in the present study. Many of the preferred codon pairs were valine amino acid-initiated, which possibly infers viral infectivity; hence the role of selecti

SUBMITTER: Khandia R 

PROVIDER: S-EPMC9961758 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature