Does Having Rheumatoid Arthritis Increase the Dose of Depression Medications? A Mendelian Randomization Study.

ABSTRACT:

Background

Rheumatoid arthritis (RA) increases the risk of depression. However, studies on the effects of RA on the dose of depression medications are limited. Therefore, in this study, we used two-sample Mendelian randomization (MR) to explore whether RA increases the dose of depression medications and gain a more comprehensive understanding of the relationship between RA and depression.

Methods

Two-sample MR was used to evaluate the causal effect of RA on the dose of depression medications. The aggregated data on RA originated from extensive genome-wide association studies (GWASs) of European descent (14,361 cases and 42,923 controls). The summary GWAS data for the dose of depression medications were derived from the FinnGen consortium (58,842 cases and 59,827 controls). R

SUBMITTER: Wan X 

PROVIDER: S-EPMC9961843 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature