Serum Androgen Metabolites Correlate with Clinical Variables in African and European American Men with Localized, Therapy Naive Prostate Cancer.

ABSTRACT: Dihydrotestosterone (DHT) and testosterone (T), which mediate androgen receptor nuclear translocation and target gene transcription, are crucial androgens and essential molecular triggers required for the proliferation and survival of prostate cancer cells. Therefore, androgen metabolism is commonly targeted in the treatment of prostate cancer. Using a high-pressure liquid chromatographic assay with tandem mass spectral detection, we determined the serum levels of metabolites produced during DHT/T biosynthesis in African American (AA) and European American (EA) men with localized, therapy naïve prostate cancer. Serum progesterone and related metabolites were significantly lower in AA men than in EA men, and these differences were associated with rapid disease progression. Multivariate anal

SUBMITTER: Ramakrishnan S 

PROVIDER: S-EPMC9962438 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature