Efficacy of Hydroponically Cultivated Saffron in the Preservation of Retinal Pigment Epithelium.

ABSTRACT: Saffron treatment is a broad-spectrum therapy used for several retinal diseases, and its effectiveness depends on a particular molecular composition (REPRON^® saffron). Its production requires specific crops and procedures that, together with low yields, make this spice expensive. To reduce costs, the use of hydroponic crops is gradually increasing. In this study, we tested the protective properties of a hydroponic saffron (sH) batch in models of retinal pigmented epithelium (RPE) degeneration. ARPE-19 cells were pretreated with 40 µg/mL saffron and exposed to different types of damage: excess light and retinol (LE + RET) or oxidative stress (H₂O₂). After analyzing the composition of all saffron types with spectroscopy, we performed cell viability and immuno

SUBMITTER: Di Paolo M 

PROVIDER: S-EPMC9962550 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature