The Conjusome-A Transient Organelle Linking Genome Rearrangements in the Parental and Developing Macronuclei.

ABSTRACT: The conjusome plays an important role in the conjugation events that occur in Tetrahymena thermophila. The conjusome appears in the anterior of conjugant pairs during the early stages of new macronuclei (anlagen) development. It lacks a membrane, and is composed of a network of fibrous, electron dense material, containing background cytoplasm and ribosomes. Several proteins localize to this organelle, including Pdd1p, a chromodomain protein that participates in the formation of chromatin-containing structures in developing macronuclear anlagen, and is associated with the elimination of specific germ-line sequences from developing macronuclei. Conjugants lacking the PDD1 allele in the parental macronucleus do not show Pdd1p antibody staining in conjusomes. Investigations were

SUBMITTER: Janetopoulos C 

PROVIDER: S-EPMC9962563 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature